Programme and Contents
Protein Cross-Linking, the European Science Foundation Transglutaminase Programme
Workshop on Transglutaminases, protein cross-linking, and coeliac disease
University of Tampere, Tampere, Finland, September 14-15, 2001
Workshop chair
Markku Mäki, University of Tampere, Finland and Laszlo Fesus, University of Debrecen, Hungary
Friday, September 14
8.30 Welcome.
8.45-9.15 Markku Mäki, Institute of Medical Technology, University of Tampere,
Tampere, Finland: Coeliac disease, gluten-induced disease entities, clinical aspects.
9.15-9.30 Discussion
9.30-10.00 Detlef Schuppan, Medizinische Klinik I mit Poliklinik der
Friedrich-Alexander Universität Erlangen, Nürnberg, Germany: Tissue
transglutaminase as coeliac disease autoantigen.
10.00-10.15 Discussion
10.15-10.45 Daniel Aeschlimann, Connective Tissue Biology Laboratories,
School of Biosciences, Cardiff, UK: Transglutaminase: protein cross-linking enzymes
in tissues and body fluids.
10.45-11.00 Discussion
11.00-11.30 Coffee break
Transglutaminases
11.30-11.50 Rolf Hilgenfeld, Institute of Molecular Biotechnology Jena, Jena,
Germany: Three-dimensional structures of transglutaminases.
11.50-12.00 Discussion
12.00-12.20 Carlo Bergamini, Department of Biochemistry and Molecular Biology,
University of Ferrara, Ferrara, Italy: Conformational states and functional properties of
tissular transglutaminase.
12.20-12.30 Discussion
12.30-12.50 Mie-Jae Im, The Cleveland Clinic Foundation, Department of Molecular
Cardiology, The Lerner Research Institute, Cleveland, USA: Cellular functions of TGII
and its associated proteins, TGII involved cellular signalling.
12.50-13.00 Discussion
13.00-13.30 Morning free discussion
13.30-14.30 Lunch
14.30-14.50 Martin Griffin, The Nottingham Trent University, Faculty of Science and
Mathematics, Department of Life Science, Nottingham, UK: Tissue transglutaminase
and the extracellular matrix in relation to stabilisation and cell surface interactions in normal
and pathological conditions.
14.50-15.00 Discussion
15.00-15.20 Peter Steinert, National Institutes of Health, Laboratory of Skin Biology,
Bethesda, USA: Transglutaminases in skin development and disease.
15.20-15.30 Discussion
15.30-15.50 Gerry Melino, University of Rome "Tor Vergata", Department of Experimental
Medicine and Biochemical Sciences, Rome, Italy: Analysis of the phenotype of the
transglutaminase 2 knockout mice
15.50-16.00 Discussion
16.00-16.20 Miklós Sárdy, Institute for Biochemistry, University of Cologne, Köln,
Germany: The role of the epidermal transglutaminase in coeliac disease and dermatitis
herpetiformis.
16.20-16.30 Discussion
16.30-17.00 Coffee break
Extracellular matrix and coeliac disease
17.00-17.20 Patricia Simon-Assmann, INSERM, Development and Pathology of the
digestive tract, Strasbourg, France: Intestinal mesenchymal-epithelial crosstalk: role of
extracellular signals.
17.20-17.30 Discussion
17.30-17.50 Thomas T MacDonald, Division of Infection, Allergy, Inflammation and
Repair, University of Southampton School of Medicine, Southampton, UK: T cell
control of extracellular matrix in the intestine.
17.50-18.00 Discussion
18.00-18.20 Marco Londei, The Kennedy Institute of Rheumatology, London,
UK: Mechanism of induction of tissue transglutaminase in celiac
disease.
18.20-18.30 Discussion
Gliadin, the trigger of coeliac disease
18.30-18.50 Herbert Wieser, Deutsche Forschungsanstalt für Lebensmittelchemie,
Garching, Germany: Potential coeliac toxic amino acid sequences of cereal proteins
18.50-19.00 Discussion
19.00-19.30 Afternoon free discussion
20.30- Dinner
Saturday, September 15
Tissue transglutaminase, T cells, antibodies and coeliac
disease
9.00-9.20 Frits Koning, Leiden University Medical Centre, Department of
Immunohematology and Blood Transfusion, Leiden, The Netherlands: The identification
of toxic T cellstimulatory gluten peptides early in celiac disease.
9.20-9.30 Discussion
9.30-9.50 Ludvig M. Sollid, Institute of Immunology, University of Oslo, Oslo,
Norway: Tissue transglutaminase and gluten T cell epitopes in coeliac disease.
9.50-10.00 Discussion
10.00-10.20 Esposito Carla, University of Salerno, Italy: Tissue transglutaminase in the
normal and celiac small intestinal mucosa.
10.20-10.30 Discussion
10.30-11.00 Coffee break
11.00-11.20 Hans Sjöström, Biochemistry Laboratory, The Panum Institute, Copenhagen,
Denmark: Transglutaminase in the small intestine of normals and patients with coeliac disease.
11.20-11.30 Discussion
11.30-11.50 Ilma Korponay-Szabo, Heim Pál Children's Hospital,
Department of Gastroenterology and Nephrology, Budapest, Hungary: Recognition of TG2 by coeliac autoantibodies - importance of TG2 conformations and cofactors.
11.50-12.00 Discussion
12.00-12.20 Roberto Marzari, University of Trieste, Department of Biology, Trieste,
Italy: Antibodies to transglutaminase from phage display
libraries.
12.20-12.30 Discussion
12.30-13.30 Lunch
13.30-13.50 Riccardo Troncone, Universitá degli Studi di Napoli Federico II,
Department of Pediatrics, Naples, Italy: Inhibition of tissue transglutaminase activity by specific antibodies from coeliac patients.
13.50-14.00 Discussion
14.00-14.20 Tuula Halttunen, Institute of Medical Technology, University of Tampere,
Tampere, Finland: The role of disease specific IgA autoantibodies in coeliac disease
pathogenesis.
14.20-14.30 Discussion
14.30-15.00 Free Discussion
Transglutaminase in cellular stress and apoptosis
15.00-15.20 Wilbert Boelens, University of Nijmegen, Department of Biochemistry,
Nijmegen, The Netherlands: Involvement of transglutaminase in the formation of pathological
inclusion bodies containing small heat shock proteins and cytoskeletal proteins.
15.20-15.30 Discussion
15.30-15.50 Laszlo Fesus, University of Debrecen, Department of Biochemistry and
Molecular Biology, Medical and Health Sciences Center, Debrecen, Hungary:
Ca-Transglutaminase; activation mechanism and action in cell death.
15.50-16.00 Discussion.
16.00-16.20 Mauro Piacentini, University of Rome "Tor Vergata", Department of Biology, Rome,
Italy: Is "tissue" transglutaminase expression in celiac disease an apoptosis associated
event?
16.20-16.30 Discussion
16.30-17.00 Coffee break
17.00-18.30 Overall discussion, conclusions, future
20.00- Dinner
Free paper abstracts
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